William S. Grubbe

This study designs allosterically controlled enzymes using denoising diffusion models, showing that activity can be activated or repressed by designed effectors.

This paper designs synthetic cytokine agonists with controlled receptor geometry to modulate signaling outcomes and functional effects.

This paper develops a cell-free system for styrene biosynthesis, achieving titers 10 times higher than cellular methods by optimizing reaction conditions.

The paper introduces iPROBE, a platform for in vitro prototyping and rapid optimization of biosynthetic enzymes, demonstrating improved production of 3-hydroxybutyrate and n-butanol in microbial cell factories.