Christopher R. L. Large

Variation in social feeding behavior and interactions among Caenorhabditis nematodes

This study examines variation in social feeding and bordering behaviors across multiple Caenorhabditis species and finds that behavioral differences do not correlate with evolutionary relatedness.

Overdrive is essential for targeted sperm elimination by Segregation Distorter

The paper identifies Overdrive as a gene essential for targeted sperm elimination in the Segregation Distorter system in Drosophila.

Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNA

The paper identifies a replication error mechanism called ODIRA that generates inverted copy number variants through template switching at replication forks, using yeast as a model system.

Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors

The paper identifies species-specific transposon-derived enhancers contributing to transcriptomic differences in human and chimpanzee hippocampal intermediate progenitors.

yEvo: Experimental evolution in high school classrooms selects for novel mutations and epistatic interactions that impact clotrimazole resistance in S. cerevisiae.

This study uses high school students to experimentally evolve S. cerevisiae and identifies mutations and epistatic interactions affecting azole resistance.

Phenotypic and genotypic consequences of CRISPR/Cas9 editing of the replication origins in the rDNA of Saccharomyces cerevisiae

This study edits rDNA replication origins in yeast using CRISPR/Cas9, revealing growth and lifespan consequences of such modifications.