Witold G. Szymanski

Cell-specific FUS loss enhances ageing-associated transcriptional elongation in lung fibrosis

The paper investigates how FUS loss in fibroblasts affects transcriptional elongation and senescence in IPF, finding that reduced FUS levels increase Pol II activity and fibrosis-related gene expression.

Immunomodulatory endothelial cells contribute to T cell recruitment and activation through antigen presentation on MHC class II

This paper identifies immunomodulatory endothelial cells (IMEC) that present antigens on MHC class II and activate T cells in atherosclerosis.

A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces p53-mediated cell cycle arrest and senescence

Microprotein miP-PSTPIP2 affects cytoskeleton dynamics to modulate endothelial cell endocytosis, barrier function and migration

This study identifies miP-PSTPIP2, an inflammation-induced microprotein that modulates endothelial cell endocytosis, cytoskeleton dynamics, and barrier function by affecting Arp2/3-mediated actin dynamics.

3D genome organization during TGFB-induced transcription requires nuclear microRNA and G-quadruplexes

The paper shows that nuclear miR-9 is required for chromatin features and promoter-super-enhancer looping during TGFB1-induced transcriptional activation.