Johannes Graumann

The paper investigates how FUS loss in fibroblasts affects transcriptional elongation and senescence in IPF, finding that reduced FUS levels increase Pol II activity and fibrosis-related gene expression.

This study identifies Yra1 phosphorylation as a mechanism that inhibits bulk mRNA export during heat stress while promoting selective export of heat-induced transcripts in S. cerevisiae.

This paper identifies immunomodulatory endothelial cells (IMEC) that present antigens on MHC class II and activate T cells in atherosclerosis.

This study identifies miP-PSTPIP2, an inflammation-induced microprotein that modulates endothelial cell endocytosis, cytoskeleton dynamics, and barrier function by affecting Arp2/3-mediated actin dynamics.

This study identifies synergistic metabolic inhibitors that selectively target ovarian and colorectal cancer cells by disrupting both glycolysis and oxidative phosphorylation.

The paper shows that nuclear miR-9 is required for chromatin features and promoter-super-enhancer looping during TGFB1-induced transcriptional activation.

The paper develops epigenetic scores (EpiScores) for plasma proteins to predict disease risk, finding 137 associations with incident morbidities independent of known factors.

The paper shows that HMGA2 induces DNA nicks required for nucleosome incorporation containing H2A.X, which is necessary for DNA demethylation and transcription initiation.

multicrispr is a gRNA design tool that enables efficient and specific gRNA creation for CRISPR-based applications like Prime Editing and large-scale screening.

The paper identifies insulin-independent modulators of glucose metabolism using a zebrafish model and finds androgen receptor antagonists reduce fasting glucose levels in insulin mutants.

This study identifies Myh10 as critical for alveolar development and ECM remodeling, linking its deficiency to pulmonary disease and emphysema.

The paper performs a GWAS on blood plasma proteome data from two cohorts to identify SNP-protein associations linked to various diseases and creates a genome-proteome network and web tool for analysis.