Author

Lachlan Ford MacBean

University of Exeter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Adam R. SmithiD· 2 shared Ehsan PishvaiD· 2 shared Giulia PegoraroiD· 2 shared Jennifer L. ImmiD· 2 shared Joshua HarveyiD· 2 shared Katie LunnoniD· 2 shared Luke Stephen WeymouthiD· 2 shared Morteza P KouhsariD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersNeuroscience

Adam R. SmithORCID

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Author profile →

3 papers

Recent·Most cited

Systemic infections alter cortical transcriptional signatures in Alzheimer's disease

Giulia Pegoraro, Lachlan Ford MacBean, Adam R. Smith, Darren M. Soanes, Rebecca G. Smith, Jennifer L. Imm, Joshua Harvey, Morteza P Kouhsar, Valentin Laroche, Luke Stephen Weymouth, Isabel Castanho, Winston Hide, Laura Palmer, Debra J. Lett, Andrew Robinson, , Katie Lunnon

This study examines how systemic respiratory infections alter transcriptional patterns in the Alzheimer's disease brain, identifying gene expression changes and pathways linked to immune and vascular responses.

Neurobiology of Aging · Jun 26, 2026Peer-reviewedNeuroscience

Epigenomic subtypes of late-onset Alzheimer's disease reveal distinct microglial signatures

Valentin Laroche, Rachel Cavill, Morteza P Kouhsar, Joshua Müller, Rick A. Reijnders, Joshua Harvey, Adam R. Smith, Jennifer L. Imm, Jarno Koetsier, Luke Stephen Weymouth, Lachlan Ford MacBean, Giulia Pegoraro, Lars Eijssen, Byron Creese, Günter Kenis, , Ehsan Pishva

This study identifies two epigenomic subtypes of late-onset Alzheimer's disease with distinct microglial and neuronal methylation signatures, linking them to different inflammatory and functional pathways.

Acta Neuropathologica · Feb 24, 2026Peer-reviewedGenomics

Inhibition of histone lysine demethylase restores learning and memory in aged mice

Shail Ratna Bhatt, Lachlan Ford MacBean, Enikö A. Kramár, Leticia Pérez‐Sisqués, Phillip Smethurst, Josephine Louise Robb, Neeru Jindal, Tracy L. Fetterly, Andrew Graham, Marcelo A. Wood, Sébastien Gillotin, Karl-Peter Giese, M. Albert Basson

This study shows that inhibiting LSD1, a histone demethylase, restores learning and memory in aged mice by reversing age-related defects in H3K4me3 dynamics and synaptic plasticity.

bioRxiv · Dec 23, 2025 · PreprintNeuroscience