Survival of the unfittest: clinical emergence of hyper-multidrug-resistant Nakaseomyces glabratus with rare nonfunctional Erg3 and Erg11 and severely impaired fitness.
Hans Carolus, Vladislav V. Biriukov, Jolien Vreys, Celia Lobo Romero, Juan Paulo Herrera Avila, Rudy Vergauwen, Dimitrios Sofras, Giel Vanreppelen, Lore Vinken, Basil Britto Xavier, Toni Gabaldón, Katrien Lagrou, Reinout Naesens, Patrick Van Dijck
The paper identifies hyper-multidrug-resistant Nakaseomyces glabratus strains with fitness trade-offs and explores nitroxoline as a potential alternative therapy for resistant UTIs.
bioRxiv · Feb 5, 2025 · PreprintMicrobiology