Author

Hans Carolus

KU LeuvenORCID 0000-0003-1507-3475Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:C. elegans· 4 Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Organism:human· 1

Frequent Co-Authors

Patrick Van DijckiD· 5 shared Celia Lobo Romero· 4 shared Dimitrios SofrasiD· 4 shared Katrien LagrouiD· 2 shared Lore Vinken· 2 shared Rudy Vergauwen· 2 shared Toni GabaldóniD· 2 shared Vladislav V. BiriukoviD· 2 shared

Activity by Year

2024-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersMicrobiology

Patrick Van DijckORCID

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5 papers

Recent·Most cited

Molecular BiologymBioPeer-reviewedSep 9, 2025

Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance?

Hans Carolus, Judith Díaz-García, Vladislav V. Biriukov…·Patrick Van Dijck

The paper investigates how Erg3 loss-of-function contributes to echinocandin resistance in Candida species by analyzing combined mutations in ERG3 and FKS2.

5 citations

C. elegansstatistical model

𝕏 PostBluesky

MicrobiologybioRxivPreprintFeb 5, 2025

Survival of the unfittest: clinical emergence of hyper-multidrug-resistant Nakaseomyces glabratus with rare nonfunctional Erg3 and Erg11 and severely impaired fitness.

Hans Carolus, Vladislav V. Biriukov, Jolien Vreys…·Patrick Van Dijck

The paper identifies hyper-multidrug-resistant Nakaseomyces glabratus strains with fitness trade-offs and explores nitroxoline as a potential alternative therapy for resistant UTIs.

1 citation

humanwhole-genome sequencing

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MicrobiologybioRxivPreprintJan 9, 2025

A comparative evaluation of CRISPR-Cas9 allele editing systems in Candida auris: challenging research in a challenging bug

Dimitrios Sofras, Hans Carolus, Ana Subotić…·Patrick Van Dijck

This study compares four CRISPR-Cas9 systems for genome editing in Candida auris, finding significant differences in efficiency and integration patterns.

1 citation

C. elegansexperimental assay

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MicrobiologyFEMS Yeast ResearchPeer-reviewedJan 1, 2025

The experimentally evolved fluconazole-resistant Clade II isolates of Candidozyma auris exhibit a distinct lipid compositional landscape, highlighting intra-clade sphingolipid heterogeneity

Praveen Kumar, Basharat Ali, Mohit Kumar…·Rajendra Prasad

This study compares sphingolipid profiles of fluconazole-resistant Candidozyma auris isolates to identify intra-clade lipid compositional differences linked to antifungal resistance.

DOI 10.1093/femsyr/foaf030

C. elegansstatistical model

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MicrobiologyNature CommunicationsPeer-reviewedOct 25, 2024

Functional Redundancy in Candida auris Cell Surface Adhesins Crucial for Cell-Cell Interaction and Aggregation

Tristan W. Wang, Dimitrios Sofras, Daniel Montelongo‐Jauregui…·Mary Ann Jabra‐Rizk

The paper identifies Als5 and Scf1 as complementary adhesins in Candida auris that promote cell-cell interaction and biofilm formation through functional redundancy.

51 citationstop 1%

C. elegansproteomics

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