Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance?
Hans Carolus, Judith Díaz-García, Vladislav V. Biriukov, Stef Jacobs, Dimitrios Sofras, Alicia Pageau, Celia Lobo Romero, Lore Vinken, Pilar Escribano, Jesús Guinea, Katrien Lagrou, Christian R. Landry, Toni Gabaldón, Patrick Van Dijck
The paper investigates how Erg3 loss-of-function contributes to echinocandin resistance in Candida species by analyzing combined mutations in ERG3 and FKS2.
mBio · Sep 9, 2025Peer-reviewedMolecular Biology