Jie Yang

The paper introduces a synthetic platform called ARESEC that enables programmable V(D)J recombination in non-lymphoid cells, enhancing antibody junctional diversity and affinity maturation.

The paper assesses axial patterning in human inner ear organoids and finds incomplete and disorganized regionalisation, suggesting limitations in self-organization and potential strategies to enhance cell complexity in vitro.

This study develops a high-throughput single-cell proteomics workflow combining nPOP with quantitative hyperplexing, achieving high sensitivity and quantification across multiple cell types.

This study designs high-fidelity CRISPR-Cas variants using a physics-driven approach combining molecular dynamics and protein language models, achieving significant improvements in fidelity with minimal experimental validation.

The paper shows that ventricular expansion in mice links hyperosmotic stress to thirst by mechanically activating candidate mechanosensitive channels.

The paper develops a comprehensive computational model of the human head to optimize visual brain-machine interfaces by simulating the entire visual pathway and surrounding tissues.

This paper introduces fluProfiler, a framework using viral sequences to predict antigenic relationships and improve vaccine strain selection by reducing reliance on time-consuming HI assays.

This study identifies and characterizes persulfidation sites in Thermococcus aciditolerans SY113, revealing their dynamic regulation by H2S and functional roles in archaeal physiology.

This paper develops a goat model of traumatic optic neuropathy with optic canal fracture to better study the condition and its effects.