Combined PARP14 Inhibition and PD-1 Blockade Promotes Cytotoxic T Cell Quiescence and Modulates Macrophage Polarisation in Relapsed Melanoma
Rotem Leshem, Kieran N. Sefton, Chun Wai Wong, I‐Hsuan Lin, Dervla T. Isaac, Mario Niepel, Adam F. L. Hurlstone
This paper shows that combining PARP14 inhibition with PD-1 blockade enhances immune responses in melanoma by promoting T cell quiescence and modulating macrophage polarization.
Journal for ImmunoTherapy of Cancer · Jan 1, 2025Peer-reviewedCancer Biology