Author

Adam F. L. Hurlstone

University of ManchesterORCID 0000-0001-5260-9457Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Organism:zebrafish· 1

Frequent Co-Authors

Adam StevensiD· 1 shared Bridget L EvansiD· 1 shared Chiara De LeonibusiD· 1 shared Chun Wai WongiD· 1 shared Dervla T. IsaaciD· 1 shared Holly Alice ShielsiD· 1 shared I‐Hsuan LiniD· 1 shared Kieran N. SeftoniD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperDevelopmental Biology

Adam StevensORCID

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2 papers

Recent·Most cited

Cancer BiologyJournal for ImmunoTherapy of CancerPeer-reviewedJan 1, 2025

Combined PARP14 Inhibition and PD-1 Blockade Promotes Cytotoxic T Cell Quiescence and Modulates Macrophage Polarisation in Relapsed Melanoma

Rotem Leshem, Kieran N. Sefton, Chun Wai Wong…·Adam F. L. Hurlstone

This paper shows that combining PARP14 inhibition with PD-1 blockade enhances immune responses in melanoma by promoting T cell quiescence and modulating macrophage polarization.

10 citationstop 5%

mousebulk RNA-seq

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Developmental BiologybioRxivPreprintDec 6, 2020

Transient grb10a Knockdown Permanently Alters Growth, Cardiometabolic Phenotype and the Transcriptome in Danio rerio

Bridget L Evans, Terence Garner, Chiara De Leonibus…·Adam Stevens

This study shows that transient grb10a knockdown in zebrafish leads to permanent transcriptomic changes and persistent cardiometabolic phenotypes in adulthood.

2 citations

zebrafishexperimental assay

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