Mario Niepel

This study identifies PARP14 as a key IFNγ-regulated mediator of metastatic progression in Ewing sarcoma through multi-omics analyses and functional experiments.

This paper shows that combining PARP14 inhibition with PD-1 blockade enhances immune responses in melanoma by promoting T cell quiescence and modulating macrophage polarization.

The paper introduces a method called Dye Drop for high-throughput single-cell assays in 384-well plates, enabling detailed dose-response analysis of small molecules in breast cancer cell lines.

The paper develops and validates a computational model showing mammalian cells use receptor abundance to encode past stimuli for relative sensing in signaling networks.

The paper introduces MERIDIAN, a Maximum Entropy framework to infer signaling network heterogeneity from cell-to-cell variability in network species abundances, and applies it to EGF-induced Akt signaling.

This study investigates factors affecting the reproducibility of in vitro drug-response assays across multiple centers, identifying context-sensitive factors that impact results.

This paper introduces a rapid method for isolating well-preserved yeast nuclei, enabling detailed structural and functional studies.