P. H. Jones

Modelling red blood cell optical trapping by machine learning improved geometrical optics calculations

This paper uses machine learning to improve the speed and accuracy of optical force calculations on red blood cells, demonstrating control over cell tilting with beam configurations.

Epithelioids: Self-sustaining 3D epithelial cultures to study long-term processes

This paper introduces epithelioids, a 3D culture system for mouse and human epithelia that maintains structure and function over long periods, enabling study of long-term biological processes.

p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition

This study shows p53 mutations in normal esophagus drive clonal expansion but are constrained by clonal competition, and LOH is critical for malignant transformation.

Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenic PIK3CA mutant progenitors in the esophagus

The paper shows that reducing aerobic glycolysis differences between mutant and wild-type cells limits the competitive advantage of PIK3CA mutant progenitors in the esophagus.

Membrane tension mediated mechanotransduction drives fate choice in embryonic stem cells

This study shows that membrane tension changes regulate endocytosis and fate transitions in embryonic stem cells.

The single-progenitor model as the unifying paradigm of squamous epithelial maintenance

This study uses lineage tracing and proliferation assays to show that squamous epithelial tissues are maintained by a single population of proliferating cells, not multiple stem cell types.

Relating evolutionary selection and mutant clonal dynamics in normal epithelia

The paper analyzes mutant clonal dynamics in normal epithelia to determine if mutations confer a competitive advantage, showing that previous metrics may misrepresent non-neutral behavior due to experimental design and tissue constraints.