Author
Columbia UniversityORCID 0009-0003-7911-881XUnclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Renjian Xiao, Americo A. Casas-Ciniglio, Hoang C. Le…·Samuel H. Sternberg
The paper identifies a TldR repressor in Enterococcus faecalis that directly represses OppA, revealing its role in regulating bacterial peptide import and uncovering a conserved structural mechanism inherited from TnpB ancestors.
Megan Wang, Kanta Yoneyama, Rimantė Žedaveinytė…·Samuel H. Sternberg
The paper shows how two reverse transcriptases with different templating strategies work together to produce complementary DNA for antiviral defense.
Florian T. Hoffmann, Tanner Wiegand, Adriana I. Palmieri…·Samuel H. Sternberg
The paper identifies a novel RNA-guided transcription mechanism using dCas12f and σE factors in E. coli, enabling gene activation without traditional promoter motifs.
Rimantė Žedaveinytė, Chance Meers, Hoang C. Le…·Samuel H. Sternberg
The paper investigates the molecular mechanisms of transposition and RNA-guided DNA cleavage in IS607-family elements, revealing how transposon-encoded RNAs balance splicing and guide RNA functions.
Tanner Wiegand, Florian T. Hoffmann, Matt W.G. Walker…·Samuel H. Sternberg
The paper identifies TnpB-like nuclease-dead repressors (TldR) as RNA-guided transcription factors that emerged through domestication of transposon-encoded TnpB nucleases, pre-dating CRISPR-Cas systems.