Author

Keith A. Johnson

Brigham and Women's HospitalORCID 0000-0002-5916-6043Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Assay:imaging· 1

Frequent Co-Authors

Reisa Anne SperlingiD· 4 shared Aaron P. SchultziD· 2 shared Hyun‐Sik YangiD· 2 shared Jasmeer P. ChhatwaliD· 2 shared Michael J ProperziiD· 2 shared Philip L. De JageriD· 2 shared Timothy J. HohmaniD· 2 shared Ana Y. BaenaiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersNeuroscience

Reisa Anne SperlingORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintNov 21, 2025

Blood-based Transcriptomics Reveal Sex- and Amyloid-Modulated Biology of Plasma pTau217 in Preclinical Alzheimer's Disease

Mabel Seto, Hannah M Klinger, Michelle J. Clifton…·Rachel F. Buckley

The paper identifies gene associations with plasma pTau217 in preclinical Alzheimer's disease, showing modulation by APOEε4, Aβ-PET, and sex, with X-linked genes playing a role.

DOI 10.1101/2025.11.21.689770

humanbulk RNA-seq

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Genetic & Genomic MedicineNature CommunicationsPeer-reviewedNov 30, 2023

Cell-type-specific Alzheimer's disease polygenic risk scores are associated with distinct disease processes in Alzheimer's disease

Hyun‐Sik Yang, Ling Teng, Daniel Kang…·Reisa Anne Sperling

The paper derives cell-type-specific Alzheimer's disease polygenic risk scores and shows their associations with distinct pathological features in AD.

48 citationstop 1%

humanbulk RNA-seq

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NeurosciencebioRxivPreprintJul 4, 2023

Functional variations in gamma-secretase activity are critical determinants of the clinical, biomarker, and cognitive progression of autosomal dominant Alzheimer's disease

Stephanie A. Schultz, Lei Liu, Aaron P. Schultz…·Dominantly Inherited Alzheimer Network Investigators

The paper quantifies Aβ production from PSEN1 variants and links it to clinical and biomarker progression in ADAD, showing strong associations with disease trajectories.

5 citations

humanbulk RNA-seq

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NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedApr 5, 2022

Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease

Edmarie Guzmán‐Vélez, Ibai Palacio Diez, Dorothée Schoemaker…·Yakeel T. Quiroz

This study examines how amyloid-β and tau pathologies affect brain functional connectivity in preclinical Alzheimer's disease carriers, finding distinct dysconnectivity patterns in specific brain regions.

92 citationstop 1%

humanimaging

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