Reisa Anne Sperling

The paper identifies an anxiety-related brain network that overlaps with Alzheimer's disease neurodegeneration and is associated with cognitive decline.

This paper develops a continuous amyloid staging score from regional amyloid PET to improve early Alzheimer's disease staging and cognitive risk stratification.

The paper identifies gene associations with plasma pTau217 in preclinical Alzheimer's disease, showing modulation by APOEε4, Aβ-PET, and sex, with X-linked genes playing a role.

The paper identifies sex-specific genetic loci associated with memory, executive functioning, and language performance in older adults through genome-wide meta-analyses.

The paper derives cell-type-specific Alzheimer's disease polygenic risk scores and shows their associations with distinct pathological features in AD.

The paper quantifies Aβ production from PSEN1 variants and links it to clinical and biomarker progression in ADAD, showing strong associations with disease trajectories.

This study assesses white matter hyperintensity severity using multimodal MRI in Alzheimer's Disease by analyzing signal measures from different MRI contrasts and their associations with clinical variables.

This study examines how amyloid-β and tau pathologies affect brain functional connectivity in preclinical Alzheimer's disease carriers, finding distinct dysconnectivity patterns in specific brain regions.

This study identifies genetic variants and pathways associated with cognitive resilience to Alzheimer's disease, finding a novel locus linked to bile acid metabolism and methylation changes.

The paper identifies genetic variants associated with Alzheimer's disease and cardiovascular risk factors, showing lipid-related enrichment and pleiotropy beyond APOE.