Finding the Goldilocks zone: Modulating glycoprotein cleavage and fusogenicity optimizes the efficacy of a candidate Crimean-Congo hemorrhagic fever virus vaccine
Jacob L. Berrigan, Stephanie R. Monticelli, Pieter Spealman, Courtney Cohen, Thomas G. Batchelor, Albert Wang, Elizabeth McFadden, Russell R. Bakken, Megan M. Slough, Ariel S. Wirchnianski, Eva Mittler, Robert W. Cross, Thomas W. Geisbert, Jesse H. Erasmus, David W. Hawman, , Kartik Chandran
This study identifies key glycoprotein residues that enhance the efficacy of a CCHFV vaccine by modulating cleavage and fusogenicity in animal models.
mBio · Oct 29, 2026Peer-reviewedMicrobiology