Jesse H. Erasmus

This study identifies key glycoprotein residues that enhance the efficacy of a CCHFV vaccine by modulating cleavage and fusogenicity in animal models.

The paper determines high-resolution structures of hantavirus glycoprotein tetramers and related complexes, revealing new insights into their organization and function, and evaluates their potential for vaccine design.

The paper shows mosaic-8b nanoparticles induce broader cross-reactive antibodies than homotypic ones, even in pre-vaccinated animals, suggesting potential for improved vaccine design against emerging sarbecoviruses.