KG-Bench benchmarks graph neural networks for drug repurposing using the Open Targets dataset, finding TransformerConv achieves the highest performance.

Bioinformatics · May 7, 2026Peer-reviewedBioinformatics

Increased ambient temperature mitigates pathology in the Ndufs4-/- mouse model of Leigh Syndrome

Melissa A.E. van de Wal, Christian J. M. I. Klein, Merel J.W. Adjobo-Hermans, Els M.A. van de Westerlo, Clara van Karnebeek, Mirian C.H. Janssen, Jan C. van der Meijden, Judith Regina Homberg, Jaap Keijer, Evert M. van Schothorst, Werner J.H. Koopman

This study shows that raising ambient temperature in Ndufs4-/- mice improves their health outcomes, including longer lifespan and reduced pathology.

bioRxiv · Oct 24, 2025 · PreprintNeuroscience

SMDT1 variants impair EMRE-mediated mitochondrial calcium uptake in patients with muscle involvement

Elianne P. Bulthuis, Merel J.W. Adjobo-Hermans, Bastiaan de Potter, Saskia Hoogstraten, Lisanne H.T. Wezendonk, Omar A. Z. Tutakhel, Liesbeth T. Wintjes, Lambertus P. van den Heuvel, Peter H.G.M. Willems, Erik‐Jan Kamsteeg, M. Estela Rubio‐Gozalbo, Suzanne C.E.H. Sallevelt, Suzanne M. Koudijs, Joost Nicolai, Charlotte I. de Bie, , Richard J. Rodenburg

This paper identifies SMDT1 variants that cause EMRE protein absence and impair mitochondrial calcium uptake in patients with muscle involvement.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · Jul 16, 2023Peer-reviewedGenetics