Author

Werner J.H. Koopman

Radboud University Medical CenterORCID 0000-0002-5340-6747Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Organism:Arabidopsis· 1 Assay:bulk RNA-seq· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Jaap KeijeriD· 2 shared Melissa A.E. van de WaliD· 2 shared Merel J.W. Adjobo-HermansiD· 2 shared Alexia van RinsumiD· 1 shared Bastiaan de PotteriD· 1 shared Charlotte I. de BieiD· 1 shared Christian J. M. I. KleiniD· 1 shared Christiane OttiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Jaap KeijerORCID

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Author profile →

4 papers

Recent·Most cited

Increased ambient temperature mitigates pathology in the Ndufs4-/- mouse model of Leigh Syndrome

Melissa A.E. van de Wal, Christian J. M. I. Klein, Merel J.W. Adjobo-Hermans, Els M.A. van de Westerlo, Clara van Karnebeek, Mirian C.H. Janssen, Jan C. van der Meijden, Judith Regina Homberg, Jaap Keijer, Evert M. van Schothorst, Werner J.H. Koopman

This study shows that raising ambient temperature in Ndufs4-/- mice improves their health outcomes, including longer lifespan and reduced pathology.

bioRxiv · Oct 24, 2025 · PreprintNeuroscience

A novel and robust method for assessing mitochondrial (dys)function in healthy and diseased frozen cardiac tissue

Liangyu Hu, Alexia van Rinsum, Rocco Caliandro, Qi Xi, Shuxiu Fan, Xinyi Jiang, Jur Massop, Melissa Bekkenkamp‐Grovenstein, Christiane Ott, Tilman Grune, Melissa A.E. van de Wal, Werner J.H. Koopman, Marcel Giesbers, Monika M Gladka, Jaap Keijer, Deli Zhang

This paper introduces TSIT, a method to assess mitochondrial function in frozen cardiac tissue, showing comparable results to fresh samples and detecting dysfunction in various mouse models and human samples.

Communications Biology · Aug 19, 2025Peer-reviewedPhysiology

SMDT1 variants impair EMRE-mediated mitochondrial calcium uptake in patients with muscle involvement

Elianne P. Bulthuis, Merel J.W. Adjobo-Hermans, Bastiaan de Potter, Saskia Hoogstraten, Lisanne H.T. Wezendonk, Omar A. Z. Tutakhel, Liesbeth T. Wintjes, Lambertus P. van den Heuvel, Peter H.G.M. Willems, Erik‐Jan Kamsteeg, M. Estela Rubio‐Gozalbo, Suzanne C.E.H. Sallevelt, Suzanne M. Koudijs, Joost Nicolai, Charlotte I. de Bie, , Richard J. Rodenburg

This paper identifies SMDT1 variants that cause EMRE protein absence and impair mitochondrial calcium uptake in patients with muscle involvement.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · Jul 16, 2023Peer-reviewedGenetics

The DEAD-box RNA helicase Dhx15 controls glycolysis and arbovirus replication in Aedes aegypti mosquito cells

Samara Rosendo Machado, Jieqiong Qu, Werner J.H. Koopman, Pascal Miesen

This study identifies Dhx15 as a host factor that controls glycolysis and arbovirus replication in Aedes aegypti cells by modulating gene expression.

bioRxiv · Jun 22, 2022 · PreprintMolecular Biology