Author

Melissa A.E. van de Wal

Radboud University Medical CenterORCID 0009-0003-9848-935XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Organism:human· 1

Frequent Co-Authors

Jaap KeijeriD· 2 shared Werner J.H. KoopmaniD· 2 shared Alexia van RinsumiD· 1 shared Christian J. M. I. KleiniD· 1 shared Christiane OttiD· 1 shared Clara van KarnebeekiD· 1 shared Deli ZhangiD· 1 shared Els M.A. van de WesterloiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

Jaap KeijerORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 24, 2025

Increased ambient temperature mitigates pathology in the Ndufs4-/- mouse model of Leigh Syndrome

Melissa A.E. van de Wal, Christian J. M. I. Klein, Merel J.W. Adjobo-Hermans…·Werner J.H. Koopman

This study shows that raising ambient temperature in Ndufs4-/- mice improves their health outcomes, including longer lifespan and reduced pathology.

DOI 10.1101/2025.10.24.684321

mouseexperimental assay

𝕏 PostBluesky

PhysiologyCommunications BiologyPeer-reviewedAug 19, 2025

A novel and robust method for assessing mitochondrial (dys)function in healthy and diseased frozen cardiac tissue

Liangyu Hu, Alexia van Rinsum, Rocco Caliandro…·Deli Zhang

This paper introduces TSIT, a method to assess mitochondrial function in frozen cardiac tissue, showing comparable results to fresh samples and detecting dysfunction in various mouse models and human samples.

4 citations

𝕏 PostBluesky