Julio Aguila Benitez

The paper develops a linear regression model to predict biological brain ageing and identifies age-related gene expression patterns linked to Parkinson's disease susceptibility.

This study uses single-cell RNA sequencing to identify shared mitochondrial dysfunction in motor neurons across FUS and TARDBP ALS mutations, suggesting common toxic mechanisms.

The paper examines changes in substance P, NPY, and their receptors in major depression by analyzing transcript levels in brain regions of suicide victims and controls.

The paper identifies stable gene markers distinguishing vulnerable SNc and resilient VTA dopamine neurons in humans and shows their expression changes in Parkinson's Disease.

This study identifies robust markers for human midbrain dopamine neurons using LCM-seq, showing they can distinguish SNc and VTA neurons in both human and mouse.

This study generates oculomotor neurons from mouse stem cells and shows they are more resilient to ALS-like toxicity than spinal motor neurons.

Axon-seq identifies axon-specific transcripts and ALS-dysregulated genes in motor axons, revealing novel therapeutic targets for motor neuron disease.