Prayag Murawala

The paper introduces a tissue-clearing framework and mesoSPIM-ultra system for large-scale single-neuron tracing in cleared mouse tissue.

The paper investigates how scaling of signaling pathways affects adult organ regeneration, finding that mismatched scaling of SHH and Wnt9a signaling prevents digit regeneration in large blastemas.

The paper develops a zebrafish model of accelerated muscle atrophy by inducing Atrogin-1 expression, showing muscle degeneration, locomotion dysfunction, and neurodegenerative effects.

This study shows connective-tissue cells are essential for axolotl limb regeneration, making up 75% of blastema cells and requiring specific signaling for regeneration.

The paper shows that vertebral segmentation during axolotl tail regeneration occurs via a buckling instability mechanism, distinct from the somite-based process in embryonic development.

The paper investigates the evolutionary origin and diversification of collagen IV genes, revealing their role in the development of basement membranes and adaptation to environmental osmolarity.

The paper identifies segment-specific chromatin states at homeoprotein loci in axolotl limb segments, showing how positional information is encoded for regeneration.

This study identifies Prrx1 enhancer-positive dermal fibroblasts as injury-responsive, multipotent cells capable of promoting scar-free wound healing.

The paper introduces a non-toxic, simplified tissue clearing method called 2Eci that enables broad applicability across multiple species and tissues.