Jonathan M. Coquet

This paper introduces PhyloTrajectory, a method that uses TCR clonotype frequencies and scRNA-seq to infer T cell differentiation trajectories.

The paper uses spatial and single-cell techniques to show T and B cell clonal expansion in CXCL9-rich niches of sinonasal cancer, linking immune hubs to tumor regions.

The paper shows JAML expression on NK cells is regulated by tumor microenvironment and MHC class I interaction, with implications for NK cell-mediated tumor killing.