Marco Mainardi

Mapping and longitudinal imaging of potentiated synapses in the mouse hippocampus using SynActive-eGRASP

The paper develops SA-eGRASP to map and track potentiated synapses in the mouse hippocampus following learning and uses it to study long-term synaptic dynamics.

The PSD-95 interactome of hippocampal synapses potentiated in response to an in vivo learning task

The paper characterizes the PSD-95 interactome of hippocampal synapses potentiated by an in vivo learning task using a genetically encoded probe and mass spectrometry.

Distinct spatial distribution of potentiated dendritic spines in encoding- and recall-activated hippocampal neurons

The paper shows that potentiated dendritic spines in hippocampal neurons are spatially distributed differently during memory encoding and recall phases.

Low forces push the maturation of neural precursors into neurons

The paper shows that mechanical stimulation via magnetic nano-pulling accelerates neural precursor maturation into neurons and alters neuronal network organization.

Nuclear Tau modulates VGluT1 expression: a new function for Tau

The paper shows that nuclear Tau regulates VGluT1 expression, linking Tau's non-canonical function to glutamatergic synaptic transmission and neurodegeneration.

A congenital pain insensitivity mutation in the nerve growth factor gene uncouples nociception from affective pain in heterozygous humans and mice

This study investigates how congenital pain insensitivity in heterozygous humans and mice affects affective pain responses, finding dissociated effects on learned fear and neural processing.