Chelsea X. Alvarado

CARDBiomedBench evaluates LLM performance in biomedical research using a benchmark focused on neurodegenerative diseases, revealing significant limitations in response quality and safety.

This study investigates the genetic role of the NLRP3-inflammasome in Parkinson's disease using polygenic risk scores and Mendelian randomization, finding no significant associations.

The paper identifies druggable target genes for neurodegenerative diseases using Mendelian Randomization and provides a web platform for exploring therapeutic targets.

Intronic GBA1 variant rs3115534-G, common in African and African admixed ancestry but rare elsewhere, raises Parkinson's disease risk (OR 1.58) and lowers onset age.

The paper identifies immune-related cell types and genetic loci associated with three neurodegenerative diseases using single cell RNA sequencing and genome-wide association studies.

This study conducts a multi-ancestry GWAS meta-analysis of Alzheimer's disease, identifies two novel loci, and assesses polygenic risk score generalizability across populations.

This study clusters patients with neurodegenerative diseases based on genetic risk variants, revealing overlapping genetic etiology and subsets with no common risk factors.

This study investigates the genetic and genomic links between NBIA and PD, finding no strong association and suggesting they may be distinct conditions.

The paper presents a detailed connectome of the adult Drosophila central brain, including new methods for data analysis and biological insights into neural circuit organization.

A dense electron-microscopy reconstruction of half the fly central brain, with nearly every cell typed and queryable online, turns months of tracing partners into a database lookup.