Zhiyuan Lu

Sexual dimorphism in the complete connectome of the Drosophila male central nervous system

The paper presents the complete connectome of the Drosophila male central nervous system and compares it to the female connectome, identifying sex-specific and dimorphic neuronal types.

Cross-species comparative connectomics reveals the evolution of an olfactory circuit

This study uses cross-species connectomics to show that olfactory circuits have conserved core elements and species-specific rewiring linked to ecological differences.

Connectome-driven neural inventory of a complete visual system

A FIB-SEM connectome of the male Drosophila right optic lobe sorts ∼53,000 neurons into 727 types, with neurotransmitter predictions and 577 matched split-GAL4 lines.

Data Release: High-Resolution Imaging and Segmentation of P7 Mouse Tissue Microarchitecture Using FIB-SEM and Machine Learning

The paper releases high-resolution 3D imaging and nucleus segmentations of seven tissues from a P7 mouse using FIB-SEM and machine learning.

A Connectome of the Male Drosophila Ventral Nerve Cord

Roughly 23 thousand traced neurons and 10 million TBars of the male Drosophila nerve cord, reconstructed from electron microscopy, typed, and queryable in neuPrint down to motor neurons.

En bloc preparation of Drosophila brains enables high-throughput FIB-SEM connectomics

The paper introduces methods to prepare Drosophila brains for high-throughput FIB-SEM connectomics, enabling faster and more accurate imaging of neural connections.

Presynaptic Mitochondrial Volume and Density Scale with Presynaptic Power Demand

The paper quantifies presynaptic energy demands and shows mitochondria scale with power demand in Drosophila motor nerve terminals.

A Connectome and Analysis of the Adult Drosophila Central Brain

The paper presents a detailed connectome of the adult Drosophila central brain, including new methods for data analysis and biological insights into neural circuit organization.

A Connectome of the Adult Drosophila Central Brain

A dense electron-microscopy reconstruction of half the fly central brain, with nearly every cell typed and queryable online, turns months of tracing partners into a database lookup.

GCIB-SEM: A path to 10 nm isotropic imaging of cubic millimeter volumes

The paper introduces GCIB-SEM, a 3D electron microscopy technique that provides <10 nm isotropic resolution for large volumes, improving z-resolution and compatibility with multibeam SEMs.