Louis K. Scheffer

The paper compares synapse detection in Drosophila EM reconstructions using SS-TEM and FIB-SEM, finding FIB-SEM detects more synapses.

A FIB-SEM connectome of the male Drosophila right optic lobe sorts ∼53,000 neurons into 727 types, with neurotransmitter predictions and 577 matched split-GAL4 lines.

The paper analyzes mitochondria in the Drosophila connectome, showing variations in size, location, and appearance across cell types and brain regions.

Roughly 23 thousand traced neurons and 10 million TBars of the male Drosophila nerve cord, reconstructed from electron microscopy, typed, and queryable in neuPrint down to motor neurons.

The paper introduces methods to prepare Drosophila brains for high-throughput FIB-SEM connectomics, enabling faster and more accurate imaging of neural connections.

The paper examines synaptic connectivity patterns in the adult Drosophila brain to infer developmental wiring mechanisms, finding support for surface protein-directed synapse formation and synapse density variations.

The paper presents a detailed connectome of the adult Drosophila central brain, including new methods for data analysis and biological insights into neural circuit organization.

The paper maps the synaptic connectivity of the Drosophila mushroom body and identifies new circuit components and structures in sensory input processing and output modulation.

The paper analyzes graph properties of the Drosophila central brain connectome, comparing them to human-designed logic systems and exploring functional implications.

neo4j-based graph data model, web explorer and HTTP/Python API for EM connectomes; on an unpublished dataset with 10s of millions of synaptic elements, most queries finish under a second.

The paper simulates neural circuits in Drosophila using extracted connectomes and shows simpler models can accurately reproduce key functions like direction selectivity.