Rik Jozef Urbain Lories

FERMT2 expression in human articular chondrocytes is regulated by hypoxia-associated transcriptional programs

This study identifies hypoxia as a regulator of FERMT2 expression in human chondrocytes, showing it enhances FERMT2 without adverse effects on ECM, while other factors like GATA1 and MEF2A also influence its expression.

Interplay between canonical Wnt signaling and α5β1 integrins modulates mechanoresponse in human articular cartilage

This study investigates how Wnt signaling and α5β1 integrins interact to modulate mechanical responses in human cartilage, showing integrins mediate Wnt-driven changes in load responsiveness.

SHIP2 deletion in cartilage does not modulate osteoarthritis in a post-traumatic mouse model

This study investigates the role of SHIP2 in post-traumatic osteoarthritis by deleting it in cartilage, finding no effect on OA progression.

Joint and tissue mechanics in post-traumatic osteoarthritis: insights from the rat model

This study uses a rat model to assess joint and tissue mechanics in post-traumatic osteoarthritis, finding no increased mechanical loading in the medial compartment despite structural changes.

Mechanical loading rescues mechanoresponsiveness in a human osteoarthritis explant model despite Wnt activation

This study examines how mechanical loading affects cartilage mechanoresponsiveness in healthy and osteoarthritic human cartilage, finding that loading rescues the chondrogenic phenotype in OA despite Wnt activation.

Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases

The paper identifies four molecular clusters in systemic autoimmune diseases using transcriptome and methylome data, showing three stable aberrant patterns and one non-specific cluster.