Jenna J Klug

A composite frailty index enables quantification of functional aging and identification of gerotherapeutic drugs in the house cricket.

The paper introduces a Composite Frailty Index (CFI) in house crickets to quantify functional aging and identify gerotherapeutic drugs.

The gerotherapeutic drugs rapamycin, acarbose, and phenylbutyrate extend lifespan and enhance healthy aging in house crickets.

This study tests intermittent dosing of rapamycin, acarbose, and phenylbutyrate in house crickets, finding lifespan extension and improved locomotion and cognition in some treatments.

Age-related cognitive decline in house crickets reveals conserved patterns of sensory and learning deficits across the lifespan

This study shows that house crickets exhibit age-related cognitive decline, including sensory and learning impairments, similar to humans, making them a useful model for studying aging mechanisms.

Morphological features of the domestic house cricket (Acheta domesticus) for translational aging studies

This study analyzes age- and sex-dependent morphological changes in house crickets, highlighting structural adaptations and environmental factors affecting aging research.

Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate slows aging in mice

A cocktail of rapamycin, acarbose, and phenylbutyrate slowed aging in mice by improving health metrics and reducing age-related lesions.