Regulation of the Rheb GTPase via GATOR1 Complex
Aditi Prabhakar, William B. Mair
This paper identifies a conserved interaction between Rheb and GATOR1 subunits that regulates mTORC1 signaling in response to nutrient stress.
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Harvard UniversityORCID 0000-0002-6024-4600Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Aditi Prabhakar, William B. Mair
This paper identifies a conserved interaction between Rheb and GATOR1 subunits that regulates mTORC1 signaling in response to nutrient stress.
Carlos G. Silva-García, Laura Ivón Láscarez-Lagunas, Katharina Papsdorf…·William B. Mair
This study identifies CRTC-1's role in balancing histone trimethylation and acetylation to promote longevity in C. elegans.
Hannah J. Smith, Anne Lanjuin, Arpit Sharma…·William B. Mair
This study shows that inhibiting mTORC1 specifically in neurons of C. elegans extends lifespan without causing growth or reproductive impairments.