Arpit Sharma

This study shows that peroxisomal dysfunction during aging reduces metabolic flexibility by impairing mitochondrial dynamics and nutrient responses, which can be mitigated by dietary restriction.

This study identifies CRTC-1's role in balancing histone trimethylation and acetylation to promote longevity in C. elegans.

The paper shows that early life activity of RNA splicing factors and lipid metabolism determine the efficacy of longevity interventions in C. elegans.

This study shows that inhibiting mTORC1 specifically in neurons of C. elegans extends lifespan without causing growth or reproductive impairments.