A simplified intermittent fasting regimen robustly extends C. elegans lifespan without FUdR or antibiotic confounds
Purbasha Dasgupta, Carlos G. Silva-García
bioRxiv · Aug 6, 2026 · PreprintPhysiology
Author
Carlos G. Silva-García
Harvard UniversityORCID 0000-0002-0434-7787Unclaimed ORCID profile · follow to get notified of new preprints
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2019-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 18 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship6 papers
Recent·Most cited
Universal Single Copy Knock-In System in Caenorhabditis elegans: One Plasmid to Target All Chromosomes
Erica Dinneen, Purbasha Dasgupta, Avinash Sharma, Khairun Nisaa, Carlos G. Silva-García
The paper introduces a universal single-copy knock-in system for C. elegans that allows transgene insertion at specific loci using CRISPR/Cas9.
G3 Genes Genomes Genetics · Sep 19, 2025Peer-reviewedGenetics
CRTC-1 Balances Histone Trimethylation and Acetylation to Promote Longevity
Carlos G. Silva-García, Laura Ivón Láscarez-Lagunas, Katharina Papsdorf, Caroline Heintz, Aditi Prabhakar, Christopher S. Morrow, Lourdes Pajuelo Torres, Arpit Sharma, Jihe Liu, Mónica P. Colaiácovo, Anne Brunet, William B. Mair
This study identifies CRTC-1's role in balancing histone trimethylation and acetylation to promote longevity in C. elegans.
bioRxiv · Aug 31, 2022 · PreprintGenetics
Confirming the Pro-longevity Effects of H3K4me3-deficient set-2 Mutants in Extending Lifespan in C. elegans
Carlos G. Silva-García, William B. Mair
The paper confirms that set-2 mutants in C. elegans extend lifespan when fed HT115 E. coli, but not OP50-1, suggesting diet-dependent regulation of COMPASS complex effects on aging.
bioRxiv · Aug 2, 2022 · PreprintGenetics
Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans
Yue Zhang, Anne Lanjuin, Suvagata Roy Chowdhury, Meeta Mistry, Carlos G. Silva-García, Heather J. M. Weir, Chia-Lin Lee, Caroline C. Escoubas, Emina Tabakovic, William B. Mair
eLife · Aug 14, 2019Peer-reviewedGenetics
Single-copy Knock-In Loci for Defined Gene Expression in C. elegans
Carlos G. Silva-García, Caroline Heintz, Sneha Dutta, Nicole M Clark, Anne Lanjuin, William B. Mair
The paper introduces a CRISPR/Cas9-based system for inserting single-copy transgenes in C. elegans with tissue-specific regulation.
G3 Genes Genomes Genetics · May 7, 2019Peer-reviewedGenetics