Author

Lester Takunda Sigauke

University of Cape TownORCID 0000-0002-6026-1304Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

David G. RusselliD· 1 shared David W. GludishiD· 1 shared Gabrielle Lê-BuryiD· 1 shared Godwin Akpeko DziwornuiD· 1 shared Grace MugumbateiD· 1 shared Jonathan T. BvunzawabayaiD· 1 shared Krishna Kuben GovenderiD· 1 shared Nyaradzo T. L. Chigorimbo‐Murefu· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperImmunology

David G. RussellORCID

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1 paper

Recent·Most cited

ImmunologybioRxivPreprintJun 23, 2024

Accessing anti-HIV activity through the attenuation of USP18 activity: novel insights from molecular dynamic simulations, free-energy profiling, and multi-cellular inhibition assays

Lester Takunda Sigauke, Jonathan T. Bvunzawabaya, Gabrielle Lê-Bury…·Nyaradzo T. L. Chigorimbo‐Murefu

This study explores using USP18 inhibition to achieve anti-HIV activity through molecular simulations, free-energy profiling, and multi-cellular assays, showing reversible non-competitive inhibition and potential for antiviral strategies.

DOI 10.1101/2024.06.23.600290

humanproteomics

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