Author

David W. Gludish

Cornell UniversityORCID 0000-0002-3537-4585Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

David G. RusselliD· 3 shared Gabrielle Lê-BuryiD· 3 shared Henry Charles MwandumbaiD· 2 shared Saikat BoliariD· 2 shared Brian HetrickiD· 1 shared Christine Mandalasi· 1 shared Dongyang YuiD· 1 shared Godwin Akpeko DziwornuiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

David G. RussellORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Screening of epigenetic modifiers identifies novel host-directed agents that suppress HIV-1 replication in primary human macrophages

Gabrielle Lê-Bury, Christine Mandalasi, Jordan M. Rhen, David W. Gludish, Saikat Boliar, Henry Charles Mwandumba, David G. Russell

This study identifies novel compounds that inhibit HIV-1 replication in primary human macrophages by targeting epigenetic regulators.

bioRxiv · Sep 4, 2026 · PreprintImmunology

Versatile HIV Rev-dependent reporter cell system for stringent and sensitive quantification of viral reservoirs, neutralizing antibodies, and restriction factors

Mark Spear, Joseph Choi, Brian Hetrick, JeongHwan Lee, Gabrielle Lê-Bury, Thuy T. Vo, Yang Han, Huizhi Liang, Jia Guo, Dongyang Yu, Subashini R. Iyer, Henry Charles Mwandumba, David G. Russell, Yuntao Wu, David W. Gludish

Retrovirology · Feb 11, 2026Peer-reviewedMicrobiology

Accessing anti-HIV activity through the attenuation of USP18 activity: novel insights from molecular dynamic simulations, free-energy profiling, and multi-cellular inhibition assays

Lester Takunda Sigauke, Jonathan T. Bvunzawabaya, Gabrielle Lê-Bury, Godwin Akpeko Dziwornu, Saikat Boliar, David W. Gludish, David G. Russell, Krishna Kuben Govender, Grace Mugumbate, Nyaradzo T. L. Chigorimbo‐Murefu

This study explores using USP18 inhibition to achieve anti-HIV activity through molecular simulations, free-energy profiling, and multi-cellular assays, showing reversible non-competitive inhibition and potential for antiviral strategies.

bioRxiv · Jun 23, 2024 · PreprintImmunology