Molecular BiologyVirus ResearchPeer-reviewed
The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models
Kim M. Stegmann, Antje Dickmanns, Sabrina Gerber…·Matthias Dobbelstein
This paper shows that methotrexate inhibits SARS-CoV-2 replication in cell cultures and synergizes with remdesivir, suggesting potential for repurposing MTX in treating COVID-19.
50 citations