The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models
Kim M. Stegmann, Antje Dickmanns, Sabrina Gerber, Vella Nikolova, Luisa Klemke, Valentina Manzini, Denise Schlösser, Cathrin Bierwirth, Julia Freund, Maren Sitte, Raimond Lugert, Gabriela Salinas, Toni Luise Meister, Stephanie Pfaender, Dirk Görlich, , Matthias Dobbelstein
This paper shows that methotrexate inhibits SARS-CoV-2 replication in cell cultures and synergizes with remdesivir, suggesting potential for repurposing MTX in treating COVID-19.
Virus Research · Jun 6, 2021Peer-reviewedMolecular Biology