Author
Novartis (Switzerland)ORCID 0000-0002-7721-6657Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Zacharias Thiel, David Marcellin, Carole Manneville…·Beat Nyfeler
The paper develops a p62-based biodegrader that selectively degrades mitochondria via autophagy but not cytosolic proteins due to its effect on p62 self-oligomerization.
Benedikt Goretzki, Maryam Khoshouei, Patrick Penner…·César Fernández Fernández
This study elucidates how BACH1 is regulated by SCFFBXO22 and SCFFBXL17 through structural changes in FBXO22 and modifications in BACH1's BTB domain, affecting its ubiquitylation and stability.
Merve Mutlu, Isabel Schmidt, Andrew I. Morrison…·Danilo Guerini
This paper identifies AK59 as a molecular glue degrader for STING, showing HERC4 is the key E3 ligase for its degradation and demonstrating efficacy against STING mutations.