Lorena Zentilin

AAV-mediated SIL1 gene therapy prevents cerebellar degeneration and ataxia in a mouse model of Marinesco-Sjögren syndrome by preserving Purkinje cells and reducing ER stress.

This paper develops a third-generation IL-2 therapeutic that targets inflamed tissues via oxidation-specific epitopes, showing improved therapeutic benefit in multiple inflammation models.

The paper characterizes the PSD-95 interactome of hippocampal synapses potentiated by an in vivo learning task using a genetically encoded probe and mass spectrometry.

This study identifies miR-124-3p as a promoter of alveolar epithelial transdifferentiation and shows that AAV-delivered miR-124 reduces bleomycin-induced pulmonary fibrosis in mice.

The paper introduces MyoRep, a reporter system that detects early muscle atrophy in vitro and in vivo, distinguishing pathological from physiological atrophy.

This study identifies autoimmune-like CD8⁺ T cell responses as drivers of atherosclerotic plaque instability and predictors of cardiovascular events in humans and mice.

This study investigates the role of SUMO2/3 modification in mitigating Tau-induced synaptic and cognitive dysfunction in disease models.

This study shows that delivering SREBP2 to astrocytes in HD mice restores cholesterol biosynthesis and improves disease symptoms.