Author

Irene Sanchez-Mirasierra

Centre National de la Recherche ScientifiqueORCID 0000-0002-6085-5698Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:Drosophila· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

Sandra‐Fausia SoukupiD· 3 shared Saurav GhimireiD· 2 shared Sergio Hernández-DíaziD· 2 shared Abdul-Raouf IssaiD· 1 shared Aida Arjona Marti· 1 shared Bertrand MollereauiD· 1 shared Carla Montecinos-OlivaiD· 1 shared Gaëtan LescaiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersNeuroscience

Sandra‐Fausia SoukupORCID

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3 papers

Recent·Most cited

The autophagy core protein Atg18 regulates exosome release and rescues pathogenic dysfunction associated to Parkinson Sac domain mutation in Synaptojanin

Irene Sanchez-Mirasierra, Sergio Hernández-Díaz, Liam Barry-Carroll, Aida Arjona Marti, Saurav Ghimire, Jean-Christophe Delpech, Sandra‐Fausia Soukup

This study shows that Atg18a regulates exosome release and rescues pathogenic dysfunction caused by a Parkinson's disease mutation in Synaptojanin.

bioRxiv · May 29, 2026 · PreprintNeuroscience

A dWDR45 knock-out Drosophila model to decipher the role of autophagy in BPAN

Marion Celle, Sahra Aniorte, Abdul-Raouf Issa, Marion Falabrègue, Haixiu Jin, Irene Sanchez-Mirasierra, Shuzhe Ding, Sandra‐Fausia Soukup, Laurent Seugnet, Lujian Liao, Gaëtan Lesca, Ludivine Walter, Bertrand Mollereau

This study generates a dWDR45 knock-out Drosophila model to investigate autophagy's role in BPAN, finding that autophagy defects contribute to some but not all phenotypes.

Human Molecular Genetics · Dec 22, 2025Peer-reviewedCell Biology

Synaptogyrin regulates neuronal activity dependent autophagy to degrade synaptic vesicle components and pathological Tau

Sergio Hernández-Díaz, Pilar Martinez-Olondo, Irene Sanchez-Mirasierra, Carla Montecinos-Oliva, Saurav Ghimire, James D. Sutherland, Rosa Barrio, Sandra‐Fausia Soukup

This study identifies Synaptogyrin as a negative regulator of activity-dependent synaptic autophagy, showing its role in degrading synaptic vesicle components and pathological Tau.

bioRxiv · Jul 4, 2023 · PreprintNeuroscience