Laurent Seugnet

This study generates a dWDR45 knock-out Drosophila model to investigate autophagy's role in BPAN, finding that autophagy defects contribute to some but not all phenotypes.

This study shows that Notch signaling in specific glial cells is essential for short-term memory in Drosophila and is modulated by dopaminergic pathways.

This paper shows that reducing Pallidin in Drosophila surface glia disrupts sleep and that this effect depends on amino acid availability.

This study investigates purine recycling deficiency in Drosophila, showing metabolic and neurobehavioral disturbances similar to Lesch-Nyhan disease in humans.

The paper identifies pallidin, a BLOC-1 gene, as upregulated in mice lacking histamine and orexin, associated with sleep disorders and altered neurotransmitter systems.

The paper investigates the role of Spen in glial lipid metabolism and its protective effect against paraquat toxicity in Drosophila.