Alexandra V. Pokhilko

This study identifies cognitive impairment and white matter defects in a mouse model of cerebral small vessel disease caused by Col4a1 mutations and shows that targeting protein folding can alleviate these issues.

This study shows that Nlrp5-null oocytes have reduced DNMT3L and impaired de novo methylation, leading to imprinting disorders and developmental issues.

The paper compares protein dynamics in mouse and human neural progenitors, finding that human NPs have longer protein half-lives and lower proteasomal activity, which influences developmental tempo.

The paper uses mathematical modeling to analyze mTOR pathway activity in human brain cells, identifying cell-type-specific responses to ligands and changes in Alzheimer's Disease.

The paper identifies a peripheral molecular clock in sensory neurons that regulates diurnal pain behaviors and shows that stabilizing cryptochromes reduces pain sensitivity.

The paper uses mathematical modeling to analyze serine integrase-mediated DNA assembly and suggests strategies to improve efficiency and precision.