Peter Spégel

Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function

The paper identifies a causal eQTL at MTIF3 associated with weight loss and shows MTIF3 deficiency affects adipocyte mitochondrial function and lipid metabolism.

Cognitive impairment and metabolite profile alterations in the hippocampus and cortex of male and female mice exposed to a fat and sugar-rich diet are normalized by diet reversal

This study shows that a high-fat and high-sucrose diet causes reversible metabolic and behavioral changes in mice, which normalize upon diet reversal.

Mitochondrial clearance of Ca2+ controls insulin secretion

This study shows that mitochondrial Ca2+ clearance regulates insulin secretion by modulating plasma membrane Ca2+ entry in beta-cells.

Perturbed Mitochondrial Metabolism in Islets from Donors with Type-2 Diabetes

The paper links altered mitochondrial metabolism to beta-cell dysfunction in type-2 diabetes by analyzing metabolites and gene expression in islets.