Author

James Kim

The University of Texas Southwestern Medical CenterORCID 0000-0002-2992-9222Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Arun K. Das GuptaiD· 1 shared Beverly A. RothermeliD· 1 shared Bret M. EversiD· 1 shared David H. MathewsiD· 1 shared Dianne ZhaoiD· 1 shared Ernesto M. LlanoiD· 1 shared Esra A. AkbayiD· 1 shared Evanthia E. PashosiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Arun K. Das GuptaORCID

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2 papers

Recent·Most cited

Cancer Cachexia in STK11/LKB1-mutated NSCLC is Dependent on Tumor-secreted GDF15

Jinhai Yu, Tong Guo, Arun K. Das Gupta, Ernesto M. Llano, Thomas Salisbury, Naureen Wajahat, Dianne Zhao, Sean Slater, Qing Deng, Esra A. Akbay, Beverly A. Rothermel, John Michael Shelton, Bret M. Evers, Zhidan Wu, Iphigenia Tzameli, , Rodney Elwood Infante

This study shows that tumor-secreted GDF15 drives cachexia in STK11/LKB1-mutated NSCLC, and blocking GDF15 reduces cachexia symptoms in mice.

Nature Communications · Jan 30, 2026Peer-reviewedCancer Biology

CRISPR/Cas9-based mutagenesis frequently provokes on-target mRNA misregulation

Rubina Tuladhar, Yunku Yeu, John Tyler Piazza, Zhen Tan, Jean Rene V. Clemenceau, Xiaofeng Wu, Quinn Barrett, Jeremiah Herbert, David H. Mathews, James Kim, Tae Hyun Hwang, Lawrence Lum

This study shows that CRISPR/Cas9-induced INDELs can lead to mRNA misregulation by creating foreign mRNAs or proteins in about half of edited cell lines.

Nature Communications · Sep 6, 2019Peer-reviewedMolecular Biology