Author

Samantha Trescott

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Approach:matrix factorization· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Nicole G. CoufaliD· 3 shared Anna S. WardeniD· 2 shared Celina T. NguyeniD· 2 shared Emily A. HanseniD· 2 shared Roy Y. KimiD· 2 shared Allen WangiD· 1 shared Arjun PateliD· 1 shared Atul MalhotraiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersGenomics

Nicole G. CoufalORCID

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Author profile →

3 papers

Recent·Most cited

Investigation of CNS damage following HIV infection and methamphetamine exposure using human iPSC-derived microglia and 3D cerebral assembloid models

Shashi Kant Tiwari, Gulshanbir Baidwan, Samantha Trescott, Shweta Jakhmola, Nicole G. Coufal, Tariq M. Rana

This study uses human iPSC-derived microglia and 3D cerebral assembloid models to investigate HIV and methamphetamine-induced CNS damage, revealing increased inflammation and neurotoxicity with reduced TREM2 function.

bioRxiv · Dec 10, 2025 · PreprintNeuroscience

Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19

Michael T. Y. Lam, Sascha H. C. Duttke, Mazen Faris Odish, Hiep Dinh Le, Emily A. Hansen, Celina T. Nguyen, Samantha Trescott, Roy Y. Kim, Shaunak Deota, Max W. Chang, Arjun Patel, Mark Hepokoski, Mona Alotaibi, Mark L. Rolfsen, Katherine Perofsky, , Nicole G. Coufal

The paper profiles the active cistrome in peripheral leukocytes of critically ill COVID-19 patients to identify severity-associated cis-regulatory elements and their regulatory programs.

Cell Reports Medicine · Jan 25, 2023Peer-reviewedGenomics

Gene regulatory networks underlying human microglia maturation

Claudia Z. Han, Rick Z. Li, Emily A. Hansen, Hunter R. Bennett, Olivier Poirion, Justin Buchanan, Jean F. Challacombe, Bethany R. Fixsen, Samantha Trescott, Johannes C. M. Schlachetzki, Sebastian Preißl, Allen Wang, Carolyn O’Connor, Anna S. Warden, Shreya Shriram, , Nicole G. Coufal

This study defines age-specific brain environmental factors driving microglia phenotypes through transcriptomic and epigenomic analysis of human fetal and postnatal microglia.

bioRxiv · Jun 2, 2021 · PreprintGenomics