Full-length structure of the anti-viral and pro-tumor DNA deaminase APOBEC3B
Ryan Abdella, Christopher A. Belica, Yanjun Chen, William L. Brown, Michael A. Carpenter, Mahmoud Ashry Ibrahim, Bárbara de la Peña Avalos, Christopher D. Mullally, Allen J. York, Reuben S. Harris, Hideki Aihara
This paper reports the cryoEM structure of full-length APOBEC3B in complex with BORF2, revealing its domain organization and mechanism of viral neutralization and mutagenesis.
bioRxiv · Jun 19, 2026 · PreprintBiochemistry