Zhilong Yang

This study identifies ZW-2038, a hydroxypyridone-3-carboxamide analog, as an antiviral lead against orthopoxviruses with low micromolar potency and selectivity in human fibroblasts and organoid models.

This study identifies ciclopirox as an antiviral agent that suppresses poxvirus replication by targeting host iron metabolism.

This study identifies vaccinia virus growth factor (VGF) as a key factor enabling mTORC1-CAD axis activation in nutrient-poor conditions, enhancing de novo pyrimidine synthesis for viral replication.

This study shows that asparagine availability is critical for poxvirus replication and protein synthesis, challenging the notion that glutamine is superior to glucose for viral replication.