Zhengqiang Wang

Discovery and Characterization of a Hydroxypyridone-3-carboxamide Analog as an Antiviral Lead against Orthopoxviruses

This study identifies ZW-2038, a hydroxypyridone-3-carboxamide analog, as an antiviral lead against orthopoxviruses with low micromolar potency and selectivity in human fibroblasts and organoid models.

Structural, biophysical, and virological mechanistic characterization of HIV-1 capsid-targeting antivirals

The paper characterizes structural, biophysical, and virological properties of HIV-1 capsid-targeting antivirals, showing improved potency and stability through chemical modifications of PF74.

Damaging the conical morphology of HIV-1 capsid by targeting the FG-binding pocket and disfavoring pentameric subunits needed for core closure

This study investigates how ZW-1261, an FGBP-targeting inhibitor, disrupts HIV-1 capsid morphology by affecting pentameric subunits and core closure.

Design, synthesis and profiling of highly potent antivirals targeting emerging drug-resistant HIV-1 variants

This paper designs and synthesizes LEN analogs with improved potency against HIV-1 and resistant variants like M66I, showing significant enhancement in antiviral activity.

Ciclopirox suppresses poxvirus replication by targeting iron metabolism

This study identifies ciclopirox as an antiviral agent that suppresses poxvirus replication by targeting host iron metabolism.