Author

Friederike Pfeiffer

University of ConnecticutORCID 0000-0002-6167-3263Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:electronic health records· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Akiko NishiyamaiD· 1 shared Alexander ReissiD· 1 shared Amin Sherafat· 1 shared Andrea SantuyiD· 1 shared Fabian Klopfer· 1 shared Henner KochiD· 1 shared Holger LercheiD· 1 shared Maya Ayash· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Akiko NishiyamaORCID

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3 papers

Recent·Most cited

Oligodendrocyte precursor cells establish contacts with somata of active neurons

Ying Sun, Peter I. Jukkola, Yetunde O. Akinlaja, Olga Garaschuk, Friederike Pfeiffer

The paper shows that oligodendrocyte precursor cells (OPCs) form contacts with active neurons, reducing their calcium signals and thereby regulating neuronal activity.

bioRxiv · Mar 28, 2025 · PreprintNeuroscience

Axonopathy and altered synaptic development in early hippocampal epileptogenesis of Dravet syndrome

Nikolas Layer, Peter Müller, Maya Ayash, Friederike Pfeiffer, Meret Saile, Fabian Klopfer, Stefano Iavarone, Andrea Santuy, Petra Fallier‐Becker, Ulrike B. S. Hedrich, Holger Lerche, Henner Koch, Thomas V. Wuttke

This study uses single-cell RNA sequencing in a Dravet syndrome mouse model to identify early transcriptomic changes and axonopathy in interneurons during epileptogenesis.

bioRxiv · Oct 4, 2023 · PreprintNeuroscience

Microglial Neuropilin-1 trans-regulates oligodendrocyte expansion during development and remyelination

Amin Sherafat, Friederike Pfeiffer, Alexander Reiss, William M. Wood, Akiko Nishiyama

This study identifies Neuropilin-1 on microglia as a regulator of oligodendrocyte precursor cell proliferation and myelin repair through trans-activation of PDGFR.

Nature Communications · Apr 15, 2021Peer-reviewedNeuroscience