Author

Margarita Orozco‐Moreno

Newcastle UniversityORCID 0000-0002-6180-7882Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:imaging· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Jennifer MunkleyiD· 4 shared Kirsty HodgsoniD· 4 shared Ziqian PengiD· 4 shared Libby BlencoeiD· 3 shared Richard BeatsoniD· 3 shared David B. SykesiD· 2 shared Li PengiD· 2 shared Lizhi CaoiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Jennifer MunkleyORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Profiling Siglec-7 and Siglec-9 ligands across the LuCaP PDX series: Implications for glyco-immune checkpoint inhibition in advanced prostate cancer

Ziqian Peng, Libby Blencoe, Kirsty Hodgson, Margarita Orozco‐Moreno, Lizhi Cao, Wayne Gatlin, Li Peng, James Broderick, Richard Beatson, Jennifer Munkley

The paper profiles Siglec-7 and Siglec-9 ligands across LuCaP PDX models and clinical specimens, showing lineage-independent glyco-immune checkpoint expression and model-dependent glycan remodelling under castration.

bioRxiv · Oct 19, 2026 · PreprintCancer Biology

Siglec-15 is a glyco-immune checkpoint in prostate cancer regulating immune evasion and metastasis

Nicoll Matthews, F. Zeng, Kirsty Hodgson, Matthew Fisher, Ziqian Peng, Libby Blencoe, Margarita Orozco‐Moreno, Ella P. Dennis, Liancheng Lu, Michelle Anne Lawson, Shenglin Mei, David B. Sykes, Dallas B. Flies, Richard Beatson, Ning Wang, Jennifer Munkley

Siglec-15 is found on prostate tumour cells, macrophages and osteoclasts; antibody blockade reduced macrophage immunosuppression, osteoclast formation and tumour growth in mice (CD8+ T-cell-dependent).

bioRxiv · Aug 10, 2026 · PreprintCancer Biology✦ In-depth digest

Comprehensive profiling reveals Sialyl-Tn upregulation and prognostic value in prostate cancer

Kirsty Hodgson, Libby Blencoe, Erin Smith, Aswini Sasikumar, Ziqian Peng, Margarita Orozco‐Moreno, Richard Beatson, Paula A. Videira, Jennifer Munkley

This study shows sTn is upregulated in prostate cancer and correlates with poor patient survival, suggesting it as a prognostic biomarker and therapeutic target.

Pathology International · Jun 1, 2026Peer-reviewedCancer Biology

Siglec-engaging immunosuppressive sialoglycans are upregulated in prostate cancer and are targetable to suppress bone metastasis

Ziqian Peng, Kirsty Hodgson, Matthew Fisher, Shenglin Mei, Margarita Orozco‐Moreno, Lizhi Cao, Michael C. Kemp, Wayne Gatlin, Louisa Donald, Feier Zeng, Michelle Anne Lawson, Dániel Ungár, David B. Sykes, David J. Elliott, Li Peng, , Jennifer Munkley

This study identifies Siglec-engaging sialoglycans as upregulated in prostate cancer and shows they can be targeted to suppress bone metastasis using a bisialidase.

bioRxiv · Nov 12, 2025 · PreprintCancer Biology